Leaflets are being handed out by the Cold Fell Action Group asking drivers to slow down and be aware of animals.
Over the years, many sheep, cows and horses have been injured or killed along the 8.5-mile stretch of road which connects Ennerdale Bridge and Calderbridge.
Bob Jones, chairman of the action group, said: “Every year we promote safe driving as the young lambs are going out so there’s a greater risk.
“We want people to take extra care on the roads.”
This year, the action group has updated its Fell Road code, which was introduced 10 years ago.
It will be handed out to Sellafield workers, as many use the road, as well as to businesses in the area.
Comments: Our rules
We want our comments to be a lively and valuable part of our community - a place where readers can debate and engage with the most important local issues. The ability to comment on our stories is a privilege, not a right, however, and that privilege may be withdrawn if it is abused or misused.
Please report any comments that break our rules.
Read the rules here