Smurfit Kappa Premier League champions Netherhall were left stunned after falling to a 2-1 defeat away at Windscale.
The home side suffered an early setback after conceding an early goal.
The Atoms slowly worked their way into the game and equalised on 30 minutes.
With just minutes to go, Windscale took the lead when a Netherhall defender headed the ball over his own goalkeeper when under pressure.
Workington Athletic continued their 100 per cent start with 3-0 win over Whitehaven Miners.
There was a brace of goals for Tom Pardini and one from Stuart Gray.
Cockermouth continued their fine start with a 1-1 draw against Workington Red Star.
Ed Gate scored for the home side and Jamie Bramley for Red Star.
Division One leaders Silloth remain unbeaten courtesy of a 5-1 victory over Bransty.
Silloth scored through Kieran Little (2), Robbie Carter, Andrew Trestianu and Ryan Hanley.
Mirehouse entertained Borough and went down 5-1.
The visitor’s goals were scored by Nick Wood (3), Robbie Watson and Liam McCulloch.
Elsewhere, Hearts of Liddesdale beat St Bees 12-3.
In the preliminary round of the GMB Union Whitehaven Cup, Aspatria hammered Whitehaven Miners Reserves 8-1 on the road.
Wayne Iredale (3), Gary Messenger (2), Richard Hudson (2) and Daryl Crighton were on target for Aspatria.
Wigton Harriers beat Carlisle City 7-2 and Whitestar were beaten 2-1 away at Cleator Moor Celtic.
Fixtures
Conway Cup round one: Borough v Bransty, Netherhall v Carlisle City, Silloth v Windscale, Whitestar v Aspatria, Workington Athletic v Workington Red Star.
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